Systematic Reviews

PHCoE produces systematic reviews that aim to identify and promote evidence-based psychological health practices in the Military Health System (MHS) using well-established and rigorous methods:

  • The Cochrane approach to conducting systematic reviews

  • The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to evaluating the quality of evidence

  • Partnership with Evidence-based Practice Centers (EPC)

Read more in frequently asked questions about our systematic reviews.


  • Present-centered therapy (PCT) for posttraumatic stress disorder (PTSD) in adults (registered protocol in the Cochrane Library)
  • ​Predictive modeling algorithms to estimate suicide risk: A systematic review and meta-analysis (registered protocol)
  • Gambling disorder and problem gambling: An evidence map (registered protocol)
  • Accuracy and efficiency of screening instruments for gambling disorder: A systematic review (registered protocol )

Systematic Reviews of Psychological Health Research to Address Gaps in Practice (Southern California EPC – RAND Corporation)

An ongoing series of systematic reviews focused on improving the identification and implementation of evidence-based treatments and approaches for psychological health conditions often experienced by service members. In accordance with the 2016 National Defense Authorization Act (NDAA) [ Reference 1 ]; the current effort aims to address variability in health care practices and outcomes to improve quality of care, patient safety, and patient satisfaction.

  • Sleep management in posttraumatic stress disorder (registered protocol)
  • Effects of medication assisted treatment (MAT) for opioid use disorder on functional outcomes (registered protocol)
  • Provider interventions to increase uptake of evidence-based treatment for depression (registered protocol)
  • Gender differences in response to alcohol use disorder treatment (registered protocol)
  • Interventions for adults with co-morbid alcohol use and depressive disorders: a systematic review and network meta-analysis protocol (registered protocol)
  • The use of technology to augment clinical care in depression and anxiety disorders (registered protocol)

Evidence Syntheses of Key Complementary and Alternative Medicine (CAM) Topic Areas (Southern California EPC – RAND Corporation)

A series of systematic reviews focused on determining the efficacy, comparative effectiveness and safety of CAM and integrative medicine (IM) approaches for psychological health conditions. The goal of this effort is to inform the VA/DoD clinical practice guidelines (CPGs), as well as to address the recommendations from the Defense Health Board (DHB) [ Reference 2 ]; and Institute of Medicine (IOM) [ Reference 3 ]; to concentrate implementation efforts on evidence-based interventions.