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Mefloquine (Brand Name Lariam®) is an anti-malarial drug which is FDA-approved for use in regions where local strains of malaria have developed resistance to other anti-malarial agents. In accordance with Health Affairs HA (Health Affairs) Policy 13-002 Guidance on Medications for Prophylaxis of Malaria, 15 Apr 13, "In areas with chloroquineresistant malaria, either atovaquone-proguanil or doxycycline are acceptable as first-line prophylactic medications. Mefloquine should be reserved for individuals with intolerance or contraindications to both first-line medications. Before using mefloquine for prophylaxis, care should be taken to identify any contraindications on an individual basis and ensure the U.S. Food and Drug Administration (FDA)-required patient information handouts are available for distribution."

On 29 July 2013, the U.S. Food and Drug Administration (FDA) issued a FDA Drug Safety Communication "advising the public about strengthened and updated warnings regarding neurologic and psychiatric side effects associated with the antimalarial drug mefloquine hydrochloride. A boxed warning, the most serious kind of warning about these potential problems, has been added to the drug label. FDA has revised the patient Medication Guide dispensed with each prescription and wallet card to include this information and the possibility that the neurologic side effects may persist or become permanent."

Below, we have provided information on Mefloquine/Lariam®, including clinical guidance, policies and directives, training material, and other resources, to assist healthcare providers and Service members and their families.

Table of Contents

Policies and Directives

DoD / Joint Forces


VA (Veterans Administration)

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Clinical Guidance

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Fact Sheets

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Other Related Information

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